Mathematical and numerical modeling of focal cerebral ischemia
نویسندگان
چکیده
منابع مشابه
Mathematical and numerical modeling of focal cerebral ischemia
Cerebral focal ischemia is a local degeneration of brain tissue induced by a reduction of blood supply. We introduce a mathematical model that includes the blood dynamics, represented by a flow in a porous medium and ion dynamics (calcium and potassium), together with other variables (energy stores, tissue integrity, oxygen and glucose) representing the biochemical events consequent to the vess...
متن کاملMathematical simulation of cerebral blood flow in focal ischemia.
A computer model was developed to describe regional cerebral blood flow and tissue oxygenation with autoregulation during focal ischemia produced by occlusion of th middle cerebral artery (MCA). This steady state model described the distribution of blood flow in the cerebral arterial system including the circle of Willis as well as the pial arterial anastomoses, and included a simplified form o...
متن کاملResearch Paper: Optimization of Transient Focal Cerebral Ischemia Model by Middle Cerebral Artery Occlusion
Introduction: Cerebral ischemia is one of the most common causes of death in human populations in the industrial communities. The need for animal models is inevitable to study the pathophysiology and treatment of cerebral ischemia in human. The current study aimed at evaluating the strengths and weaknesses of different techniques used to create ischemia in previous studies and optimizing the tr...
متن کاملFocal Cerebral Ischemia
We investigated the temporal threshold for focal cerebral infarction in the spontaneously hypertensive rat The right middle cerebral artery and common carotid artery were occluded for 0,1 ,2 ,3 ,4 , or 24 hours, and all the animals were sacrificed 24 hours after the onset of ischemia. Cortical infarct volumes and edema volumes were quantified in serial frozen sections of hematoxylin and eosin-s...
متن کاملBehavioral Changes in Combination Therapy of Ethanol and Modafinil on rats Focal Cerebral Ischemia
Introduction: Ethanol is considered as an effective agent in reducing brain stroke injury. In this study, we assessed the effects of modafinil along with ethanol as a combination therapy on behavioral function in Wistar rats. Methods: The right Middle Cerebral Artery Occlusion (MCAO) was performed and the rats were divided into nine groups (n=8 per group). The animal groups in this study were ...
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ژورنال
عنوان ژورنال: PAMM
سال: 2007
ISSN: 1617-7061,1617-7061
DOI: 10.1002/pamm.200700131